Some resorts have large enough in-room safes to hold a laptop and if yours does, use it.
You can store it in the safe deposit boxes at the front desk but it is inconvenient to have to go back and forth to drop it off or pick it up.
While it is unlikely that it will be taken from your room, it is possible and it has happened. No security system is going to thwart a determined and skilled thief, but most hotel room thieves are going for the quick score and anything that will slow them down is likely to make them move on and look for that kind of opportunity. Hiding a laptop is a good first level of security, locking it in a suitcase will be a good idea too, or hiding it and securing it with a cable lock is another option. Just leaving it out in the open turns it into the quick score target that hotel thieves are looking to find.