I pack all of mine and my kids' clothes in 1-gallon ziploc bags (from dollar store - cheap ones). I put one rolled matching outfit in each bag (t-shirt, shorts, underwear, socks). That way, we know that each bag contains one cute, matching outfit with no decisions to make in the morning - just grab a bag.
I find that when I do this, I don't pack as much. The ziploc bag outfits are very compact as you squeeze all the air out before you put it in the suitcase.
Once the outfit bags are emptied, I have a lot of uses for the empty ziplocs - Keeping receipts together, wet bathing suits. There really are a thousand uses for them on vacation.
I also have a "foot care kit" which is kit with moleskin, scissors, blister band-aids, etc.. I've always made it clear that we stop immediately if you feel a hotspot on your foot and fix it. A bad blister has the power to really dampen a vacation that includes so much walking. My kids have always laughed at it, but shown it off proudly when we talk to friends about how serious I take Disney
I am a HUGE fan of the pop-up laundry hamper! We take it everywhere with us now - long and short trips. Really keeps the hotel room tidy.