BF's mom just bought a Toyota Sienna this year, based on her mechanic's recommendation. She loves it. Great ride. Toyota's are very reliable too.
She HAD a '94 Grand Caravan that she took excellent care of, and it died this year because of transmission problems. She poured lots of money into fixing it prior to this, and it didn't have a lot of miles on it. Mechanic told her to get a Toyota, so that's what she did.
I also have friends with Odyssey's and really like them. However, one complained about how the doors can be dangerous with children, and she thinks the ride in the Sienna is a bit smoother.