You were warned...
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Basically, Mission:Space is a combination of a centrifuge and a motion simulator. Think of it as the Rotor meets Star Tours. You get into a pod to simulate a trip to Mars. The pod is at the end of the arm of a 10-armed centrifuge that spins to produce G-forces. This motion, combined with the video effects on your monitor, makes you feel like you are blasting off and then traveling in space. Honestly, I've never felt the spinning and I've ridden over 20 times to date.
In addition to the spinning (which continues at varying speeds for the entire trip) each pod tilts like a motion simulator to simulate turbulance and the bumps of landing.
Because of the two different types of action (spinning and simulator) there are two groups that need to consider if this ride is right for them - those who cannot handle spinning (think Teacups) and those who cannot handle motion simulators (think Body Wars). However, I know people who cannot ride the teacups but have no problems with Mission: Space. Personally, I have not seen people coming off the ride and getting sick and I've spent hours at the pavillion. There was only one time that I saw evidence that someone had been ill. When you consider that I've ridden 20+ times and there can be up to 120 people (I've only seen 3 centrifuges running at any one time) riding at one time, I'd say those aren't bad numbers. I've seen more people getting sick riding Rock-n-Roller Coaster and Tower of Terror.