Naples is two hours from here, VB is a little over two hours from here. I am on the corner of where 75 stops going North and starts going West. 4 1/2 hours.
I am not sure if there is a better way to go across Florida, Naples is due west of here on 75.
Do a yahoo map, go to www.yahoo.com, click on maps, click on driving directions, enter the two cities, and you will get a map from city center to city center. You can enter adresses if you have them, but the cities will give you distance and driving time.
"From each according to his ability, to each according to his needs", Karl Marx, pretty sick, huh?