I am going to be in a wheelchair for our trip coming up this weekend. I wondered the same thing. I have a touringplans account.
I am normally pretty commando without a wheelchair, so giving up that freedom to race through the parks is hard for me.
While spending hours before your trip optimizing for all of the programs sounds like a good investment, I came to the realization that the wheelchair lines and wait times for attractions with a
DAS are going to be optimized naturally by using a standard touring plan. I did this at Disney World last May. By doing the major attractions early as recommended in a touring plan, I did not have to constantly get return times and figure out what to do in the meantime. Instead, because the waits were already less than 10-15 minutes for standby, the CMs just let us right on the rides. Of course there I was not prepared for any wheelchair accommodations (I assumed all lines were mainstream, so it was a surprise to be directed elsewhere or occasionally get a return time ticket). Honestly, the wheelchair line and return time tickets sometimes saved us time, but sometimes they made things take longer than standby, so it all evened out.
Since you have several children with you, get their input for attractions they want to see, especially if you know they will want to ride some rides multiple times, and then get the touringplans software and plug everything in. It should hopefully give you an optimized version. From there, if you know there are accommodations because afternoon waits, etc. are longer, then maybe look around on the map to see if there is a ride with a typically short wait time. After you print out your touringplan, just add a note of close by rides you could do while you wait for your return time. Or you could use the wait time to shop, get snacks, have bathroom breaks, or sit quietly if your DS needs a break.
I am using a standard custom touringplan. None of the lines are very long in my plan, so I think that things will work out just about right. If we are ahead of schedule, all the better! But at least I won't get frustrated for hours in the Space Mountain wheelchair line where only one person can ride at a time because I know that waits eventually even out.