DJT,
In Orlando, we have rented from Alamo, Hertz and Thrifty.
Thrifty was the cheapest but we would never rent from them again.
The shuttle service from the airport was fine, it was everything else. Got the wrong type of car (needed 4 door but got a 2 door, which is a bit tricky to get 2 car seats in).
Insisted our credit card didn't cover insurance. Argued that it did but didn't believe us until we called the credit card company to confirm. Tried to sell us other insurance we didn't want.
There was other stuff too about them, basically poor customer service. After 1.5 hrs we finally got out of there with a car.
If you don't mind the hassle for the price, then go for it.
Personally, we will pay more for good customer service. It would make us feel better knowing that if something were wrong with our rental, then the company that had the best customer service would make things a lot easier for us.