We leave our A/C on all the time. I work from home, but even if I am out, it is too hot here that it would be a waste of energy to cool down the house; plus we have pets. We keep the downstairs at a higher temp than upstairs but do not adjust it at night (usually it doesn't run much if at all downstairs at night except when it is exceptionally hot outside and the nighttime temps don't go down much). In the spring and fall, I usually increase the upstairs temperature during the day when I'm here by myself and turn it back down before dinner so my heat-sensitive family can sleep well; I don't bother in the summer since it gets too stuffy if the air isn't running. When we go away for a few days, we raise both thermostats so the A/C doesn't run as much but keep them on, otherwise it would be an oven in here when we returned.