I made most of mine up in Microsoft Word. I just set the page size to index card and the font size to 7 or 8. some are just sections of my excel spreadsheet printed to fit on an index card, and some of it is just shrunk down on my printer to fit.
I've probably gone WAY over the top with mine...but I'm OCD and neurotic!

I have 43 cards printed front and back, laminated and held together by 2 rings to make it into a small book. In it I have: transportation tips, park/EMH hours, flight/rental/room info and confirmations, important phone numbers, resort info, passporter maps shrunk down and cut in half so they line up, ADRs, estimated tips for each meal, show/character greeting times, expected weather, touring plans, closures and rehabs, tips and hints, Monica's cards from TGM (which you'll know about if you've signed up for TGM and gone into the community forums), tips for my camera settings, and a mark-off sheet to keep track of our dining credits.
Most of it was just cut and pasted from info I found on here and TGM. Some of it is info from my spreadsheet. It sounds like a lot and it probably is, but it's not as bad as it sounds. I have a card for each day and it looks something like this (although formatted much better and color coded by day!

) :
Thursday - January 24, 2008 (Arrival Day)
Disney Hollywood Studios
9:00 AM – 7:00 PM
Expected Weather: High 73 Periods of Rain/Low 58 Mostly Cloudy
Lunch: 12:15 PM – Sci Fi –XXXXXX ($13.06)
Dinner: 5:05 PM – 50’s Primetime –4XXXXXX ($13.52)
Event and Show times:
Stars and Motor Cars Parade 3:00 PM
Lights, Motors, Action! (1:20, & 4:15)
Beauty and the Beast (10:45, 12:00, 1:45, 3:45, 5:00) arrive 30 minutes early)
Fantasmic! 7:00 PM (Back rows are best) 30-45 minutes early
High School Musical (9:35, 10:35, 11:35, 1:00, 3:45, 4:45pm)
Touring Plan:
Arrive Between 10:30 and 11:00
Get Rock 'n' Roller Coaster FASTPASS
Ride Tower of Terror
11:35AM High School Musical 2- School’s Out
12:10PM Lunch @ Sci Fi Dine In Theater
Get Fast Pass for Lights, Motors, Action!
1:45 PM Beauty and the Beast (arrive 20 min Early)
Rock’n’Roller Coaster
Jim Henson's MuppetVision 3D
Great Movie Ride
4:15 PM Lights, Motors, Action! (arrive 15 Min Early)
5:05 PM Dinner @ 50’s Primetime Café
7:00PM Fantasmic (arrive 45 Min early)
Closures:
Mickey Avenue closed through at least Spring 2008 for installation of the Toy Story Mania attraction.
Journey into Narnia will be closed from January 2 - May 23, 2008
All of that fits on one card.
I have a printer that prints both sides of the paper and then I just run it through my xyron to laminate them.
Yeah, I know...I need help.
