Being someone from San Diego, I would have the say the San Diego zoo. My husband is from LA and he said that San Diego kicks LA's Zoo's butt! It seems like it would be a lot closer to Anaheim to drive to LA but with traffic, it is sometimes quicker (time wise) to go to San Diego. I've been to both Zoo's and I have to say that I do like both of them. Either way, I think you will have a great time at either Zoo!