We were just in 2601 and although it wasn't dead quiet, it wasn't so noisy that we couldn't sleep or hear each other or the TV. It was quieter than the trip on the airplane.
Also, it was between the midship and aft elevators/stairs, convenient to debarking locations and close to Parrot Cay, where we ate the last two nights and last breakfast.
We found that it was a fine location, convenient to some things but not to others. I don't know that there is a perfect location on the ship, but I had no complaints about where we were and didn't feel as though we were in a lower class area by any means.