LOL! When I read The Amityville Horror I was home alone at night. Since DH had purchased the book for me from a used bookstore, I convinced myself the book was haunted or possessed or something. When DH came home well after midnight, I made him go outside and throw the book in a dumpster, I was so worked up. Before he had a chance to read it!!
Recently, I had difficulty sleeping after reading Patricia Cornwell's Case Closed. It's non-fiction and about the identity of Jack the Ripper. There are autopsy photos and horrible descriptions and it bothered me very late at night, though I couldn't put it down.
But the book that had the biggest effect on me was one I, ironically enough, didn't read. American Psycho. I only skimmed through parts of it which were so horrible, offensive and disgusting it actually ruined part of our vacation (we were in Scotland and DH had bought the book to read on the plane). I got irrationally angry at DH for even wanting to read it and I was preoccupied and bothered by it while we were touring great castles in London and Scotland.
When we got home I made DH throw that one away too. I'm really not a book-destroying wimp, but that book really bothered the heck out of me.