Here are Mapquest directions from Old Key West to Mary Queen of the Universe which is where I always go. It is only about 4 miles away.
From: 1510 N Cove Rd Lake Buena Vista, FL 32830-8421 US
To: 8300 Vineland Ave Orlando, FL 32821-6801 US
Driving Directions
1. Start out going NORTHWEST on N COVE RD toward PENINSULAR RD. (0.01 miles)
2. Turn RIGHT onto PENINSULAR RD. (0.15 miles)
3. Turn RIGHT onto DISNEY VACATION CLUB WAY. (0.85 miles)
4. Turn RIGHT onto E BUENA VISTA DR. (0.86 miles)
5. Turn LEFT onto HOTEL PLAZA BLVD. (0.84 miles)
6. Turn RIGHT onto FL-535 S/S APOPKA VINELAND RD. (0.54 miles)
7. Turn LEFT onto VINELAND AVE. (0.91 miles)
8. End at 8300 Vineland Ave Orlando, FL 32821-6801 US
Total Estimated Time: 9 minutes
Total Distance: 4.16 miles
From the Poly, exit the MK heading towards Fort Wilderness. Go past FW and then take a right onto Bonnet Creek Pkwy. After you pass Port Orleans, take a left onto Disney Vacation Club Way and follow the above directions from step 3.
http://www.maryqueenoftheuniverse.org/index.html