If at POFQ, request top floor. If you're in POR Alligator Bayou, you'll also want top floor. We have found at POR Mansions that the buildings are built such that we have never noticed upstairs neighbors, but we still request top floor to avoid folks walking right outside our door.
Also at POFQ, you may want to request Buliding 7. It's out of the way (but still not far from anything because it's French Quarter, and you're NEVER far from anything!). In general, we book Garden View at POFQ, but some of our quietest rooms have been standard view in Building 7. If you book standard, I recommend requesting "top floor in Building 7". Building 1 is also a possibility. If you book Garden View, there are lots of quiet rooms. As long as you aren't next to the pool or on a thoroughfare near the main building, you're probably OK. I don't recommend booking river view if you're concerned about noise; too many rooms subject to boat noise.
POFQ is awesome at granting quiet room requests. Since I don't want to be where other folks want to be, it makes the room assigner's job easy! They're inundated with requests for Building 4, so when they get requests for Building 1 or 7, it's easy for them to make me happy!