I have a daughter (25 years old) that lives in Reno. I went and visited her a couple months back. We did a day drive around Tahoe and I was very much.... Meh. Of course, I lived in Colorado for almost a decade (1993-2002).
Far prettier sights to see higher up in the Sierra Nevada, like Yosemite and Sequoia.
I have never been to Yosemite, but have been to Sequoia at least a half dozen times. I LOVE the Sequoia National Park. Again, never been there, but from what I hear, Yosemite is much more built up and accessible... that is, closer to San Fran, and the crowds reflect that.
Sequoia is more "off the beaten path".
I LOVE crystal cave.
http://www.sequoiahistory.org/default.asp?contentid=632
The hike up to Tokopah Falls....
http://www.nps.gov/seki/planyourvisit/gfdayhikesum.htm
Here are a few pics of my last trip there....
And those pictures I took with my cheap digital camera do not BEGIN to do it justice.
If it were me, I'd do something like....
Fly into San Fran, and at least do a quick drive over the GG bridge, a short harbor cruise, and a ride over to Alcatraz. Can easily do all that in a day.
Then, it is a 2-3 hour drive from there to Monterey.. BEAUTIFUL!
From Monterey, it is about 4 hour drive through the California farm land to the entrance to Sequoia, then a couple more hour drive up into the park... the road can be a tad scary at points, but there is no hurry.
From Sequoia down to Anaheim is probably about 5 hours. You happen to go right past Six Flags Magic Mountain if anyone in your family likes extreme coasters.