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DAS has worked wonders for us, even though we had really enjoyed the GAC in past years. I have twins as well, one on the mild end of the spectrum and 1 who is recovering from autoimmune encephalitis and has many autistic symptoms. They are 6.
First a word of encouragement - with solid planning, Disney can be an exceptional vacation for families who deal with neuro issues! It is our favorite family place to go, and we really feel more "typical" there than anywhere else.

Secondly, it can be overstimulating and tiring for ANYone. You won't be able to do or see it all, so don't ruin your enjoyment by trying. Honestly, it's a pricey vacation and people often want to squeeze all of their money's worth out of it - but the problem is that they end up squeezing the fun out too.
Following is a list of things that help us. Obviously all families are different, so take whatever might work for you and have a super magical time!
-If possible, plan on going at a less crowded time. Crowd prediction calendars are readily available and pretty darn accurate.
-Study all of the park maps, and really familiarize yourself with the lay of the land.
-Develop a touring plan that takes advantage of shorter waits by enjoying the attractions in a certain order, and prebook your fastpasses.
-Go the parks early! Aim for being at the gates 15-30 minutes before rope drop, which means you must take into account travel time to the park, parking or bus drop, walking to the gate, etc.
-Consider driving to parks so that you can exit as needed with less crowd issues.
-Get your DAS card and a stroller as wheelchair tag as soon as you get to the park. Ask a cast member to show you to the location.
-Before leaving for your trip, ask your doctor for a handicap placard for your car, allowing closer parking.
-Don't be afraid to take a break - the park's are usually most crowded in the period after lunch to before dinner so 1-4 is a great time slot for breaks.
-Pack a survival kit - include lots of favorite snacks and drinks in individual portions, reinforcers, fidget toys, comfort item, bandaids, ziploc baggies, change of clothes, and the like.
-Bring ipod or device that will play favorite movies or games, and headphones.
-Take a photo of your kids each day when you unload in the parking lots. That way if one gets lost, you can show the CMs the photo.
-Use character dining and let the characters handler know that your kids have needs before the interaction begins.
-Go to the second parade - it's much less crowded.
-Consider showering during your break and have PJs in the car.