I think at this point its been well written enough on what side of the fence your on regarding stopping or not stopping so I will stick to your original question. We have driven from MA regularly for the past 12 years with our now 4 kids. All took some form of the trip since they were 6 months old. At this point they are use to it. We settle them into the car with a blanket, pillows, stuffed animals, games, devices, and movies. We have a bag of food, drinks, and a mini fridge plugged in for milk, yogurt, etc, paper towels for spills, wet wipes, a few plastic bags for trash - emergency vomit bags. At stops the kids will sometimes get out to stretch their legs unless its the middle of the night, then they are usually sleeping!!! We start our trips mid days and at night time time we do change them into pajamas (leaving sneakers/flip flops by the door for when they have to use the bathroom). Now a days they have the ability to stream content to their devices or the TV in the car (you tube kids is a fan favorite). I get jealous that I'm sitting in the front and can't watch it myself!!! The drive down is always so much fun with anticipation and excitement. Not gonna lie, the drive back can stink, not as exciting pulling into your own driveway as it is driving through the Earful Gates!!! Good luck and I hope everything goes well!!
PS - Drink plenty of water, no better energy drink than water. Plus stopping more to use the bathroom helps keep you alert!!!