I'll second Pacino's but your mileage may vary depending on who's cooking. Their Frutti Di Mare and Tiramisu were very good.
If you head east to the intersection of 535, there's a Smokey Bones BBQ that has good reviews. I'm heading there at some point to try them.
Celebration has a few good restaurants as PP stated. I'm trying to go to the Columbia restaurant, which has a great reputation for Cuban food. (Bongos lost its way long ago).
You have to go to Krispy Kreme on Polynesian Isles Blvd. if you haven't had them before. Macaroni Grill is there too and I'm a fan.
Old Town has some fun but it has gotten cheesy over the years. Try it on an event night like a car show for a bit more life.
192 has some life left in it, but has taken a beating over the years. I'm guessing you're driving if you're there. Don't be afraid to take a ride over to I-Drive and other nearby areas. Take I-4 East for a couple of exits and hop off at the Sea World exit. There's some great food, shopping, and entertainment along I-Drive (a good amount for the over 21 crowd) but enough for kids as well. Pointe Orlando is a hidden Gem because a lot of people drive by the big upside down building and that's all they notice. Great food in that mall. Sand Lake Road has great food also, if you head west on it from IDrive, you'll find Dr. Phillips and Restaurant Row. Just before Restaurant Row is Turkey Lake road. If you head south on that, it will go all the way back to 535 (DTD) via Palm Pkwy, and help you avoid I-4 / I-Drive traffic. There is another Wal-Mart, a NYC Bakery, Whole Foods, Anthony's pizza, great Chinese food at Taste of Asia, big post office, hospital... just quite a few hidden things.
If you find the Publix and Walgreens across and left from Old Town, that street between them is an extension of I-Drive (International Drive South). Follow that to 535 (dead end) and make a right for
Walmart (535 will dead end at 192 / Smokey Bones), or a left for more food and DTD area. If you turn right at 536 and make a left at the sign for IDrive south, it will lead you to the rest of IDrive via the local route. If you continue on 535 past 536, you will find Bahama Breeze (good food) just before the intersection of I-4 and 535. If you continue past I-4, there are many more great restaurants, and the 535 gate to DTD.