Lisa , that is my old stomping grounds - no concerns about driving there!!
I love Boston, but after a few yrs of driving in and out to Mass General along Storrow Drive for Roger, I really dislike driving into Boston proper.
Lisa, there is so much to see and do in Boston, that narrowing it down to just a few things would be very tough. You have to get to the Science Museum, the Boston Tea Party Ship, and if you're going north of the city, try Salem where they held the Salem Witch Trials - awesome!!!