Many other variables to consider. If you live in a city with a hub airport for one of the major airlines, you can generally fly non-stop at reasonable prices. Live in a small city with only a small commuter airport, your choices are likely limited. If you live someplace that is 2-3 hrs from a large airport, choosing a vacation destination that requires flying wouldn't be my first choice. Deciding WHERE to go on vacation seems like more of a consideration. What is your budget and what are your interests as it relates to your vacation? When you travel also makes a difference since airline prices around major holidays tend to be higher due to the volume of people traveling. If you know your will be flying over a holiday, best to purchase your tickets as soon as plans are finalized. Once the lower price seats sell out, you will have to pay the fare of the next higher priced tickets. Planning a vacation that is not during a major holiday can result in lower prices for not only airline tickets but hotel accommodations as well.