Our first time attending in 2008, DH was "That Guy" and we've been several times since. We've noticed that the area "That Guy" sits in always tends to be the same -- about 4-5 rows back, near the aisle on the center but in the right hand section of seats, those closest to the entry doors.
We like how the show changes based on guest interaction so it's never the same.
Plus, bonus, they give you a "I was THAT guy" sticker with Mike Wysowski on it as you leave.