We made the drive from just north of Milwaukee a few months ago. To avoid Atlanta, and to see a different part of the country including the Great Smokey Mountains, we went through South Carolina and then down the east coast. Here's the basic route --
https://goo.gl/maps/a5ZOD
It adds maybe an hour or a little more to the drive compared to the traditional route down I65. We stopped in Grenville, SC for the night.
Full disclosure, I will say that we had a miserable drive and I'm going to stick with the more straight forward route from now on. But I made the drive on less than an hour of sleep, left two hours late in thick fog, hit construction that held us up for over an hour, drove through the tail end of the Smokey Mountains in complete darkness, and arrived at our hotel completely exhausted and almost falling asleep at every stop light. So my first impression of this route was not a good one. But others I've spoken to have nothing but good things to say about this route. Your mileage may vary.