Not sure what the definition of "major bridge" is, but I do know that the
George Washington (over the Hudson) and the Delaware Memorial (over the Delaware....sorry I had to put that in!!) are 2 "significant" bridges when traveling I-95. There's a tunnel in Baltimore and after that I think, but don't know for sure, you are okay. Seeing that you're from Central NY you could
probably bypass both if you go through PA? I'll leave that to someone else! Good Luck!
You can't get past Richmond without taking a bridge over the James River. The James River Bridge is part of I-95. This site shows some good overhead views of it. Using I-295 to the east side you'll have to take the Varina-Enon Bridge, seen here. Using Route 288 to the west side you'll have to take the WWII Veterans Memorial bridge, seen here.
I don't know if any of these would qualify as "major bridges", but after Richmond I think you'll be fine until the Savannah River from SC to GA.
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