We start our north-of-Boston to WDW road trips around 3 AM, so we get past all the big cities before rush hour, and we end up in the DC area after their rush hour. We do stop on the way down (usually in South Carolina) for an overnight in a motel, and get to WDW mid morning the next day. That way, the kids aren't so cranky from being in the car, and hubby isn't wiped out from driving all night.