Your best route would be to:
Take Sepulveda South for about 1/4 mile to the 105 freeway East. Take that to the end, which will take you to the 605 freeway South. Stay on the right & the next exit or two will take you to the 91 freeway East. Get in the carpool lane & stay there. From the carpool lane take 5 freeway South. Around Euclid or so, get out of the carpool lane. You'll see a sign for Disneyland Drive. You'll want to get off at the next exit, which is Harbor Blvd. Turn right. The Howard Johnson will be on the left side, and Disneyland will be on your right.
Sepulveda south
105 East
605 South
91 East
5 South
Harbor Blvd south