I've done part of this route--NYC to Orlando--several times, although not in last 6 or 7 years.
A room or roomette is a necessity unless you don't mind sitting in a possibly extremely noisy coach seat and getting little to no sleep for, in the OP's case, 2 days.
The train can be fun, an adventure. But it can also seem like a huge slog.
If you have special dietary needs, it's probably better to bring your own food. And, even if you don't have any special dietary needs, it's good to bring food with you since I've had a couple of trips from Orlando to NYC where they ran out of food.
As a PP stated, this can be a very very very long trip. Freight has the right of way on the train lines, and sometimes the passenger train is stopped for many hours waiting for the freight train(s) to pass. I was also on this route once when the train was delayed for such a long time--they never told us what the matter was--that they were planning to take the passengers the rest of the way to Orlando by BUS. Yes, bus. And the train was perhaps 12 hours away from Orlando at that point. It didn't happen, but I was in a very bad mood during the time when it seemed like that was going to happen.
The killer for me was two trips in a row where someone in the roomette car DH and I were in was smoking nearly the entire trip and there was no way to pin down what roomette or room they were in. The secondhand smoke was intense. Even though smoking is prohibited on Amtrak, that doesn't stop people from doing it surreptitiously. And it's not like being on an airplane, where the smoker can be easily found. This pretty much killed my ever wanting to take this train again. Granted, this doesn't always happen.
And, finally, if you're going to be traveling during the winter, your entire trip can be screwed up, hugely delayed, or outright canceled, because of snow. Yes, that's happened to us.