They are very easy to use,a but let me warn you, the Mickey heads don't work so great. I promise, others you use will be easier.
1. Make sure you have a mat and a firm surface.
2. You can just eyeball it, or else make a small mark on your paper where you want your eyelet placed.
3. Take your eyelet hole tool and place on your paper on top of your mat. Hammer a couple of times. It should produce a hole.
4. Stick your eyelet in, turn the paper over and put your eyelet setter in the hole. Give it a few good pounds. If the eyelet doesn't go all the way flat, just pound a few more times without the setter. Not so hard though that you take off your paint on the eyelet on the other side.
Good luck! And may I suggest you practice once before you actually put one on your layout.