Yes, with both of my pregnancies. With my first I had to go to the hospital to get re-hydrated (never admitted) several times. I was throwing up a good 15 to 25 times a day and unable to eat or drink anything except bread and rootbeer (which most of the time didn't stay down). All the could give me was Phenergan suppositories, which didn't really help. It lasted until my seventh month.
My second started out the same way, but I was prescribed Zofran. Very very expensive (I think I figured out that if I took as much as I could have taken it would have cost about $400 a week!), but luckily I only had to pay $40 about every two weeks through my insurance. It was a wonder drug for me. I still felt nauseated, but I wasn't throwing up anymore.