From Columbus, OH -
978 miles if I take the East route down I-77 (WV Turnpike) to I-95 to I-4.
1012 Miles if I take the West route down I-75 to the FL Turnpike.
I usually take the West route to avoid the WV Turnpike; it's a real pain to drive on when pulling a camper. Even though it's a longer route to the West it's usually a little quicker because the roads are less curvy and hilly. It also depends on if I can get through Atlanta without hitting rush hour. I guess its kind of a a toss-up weather to go through Atlanta or Orlando, both are often bad.
I make the trip at least once a year, more often if I can (the years are listed in my sig).