we are having a custom wedding but have still been able to keep our list at 66. we are having family only with 2 friends as our bridal party. the way we were able to keep the family guest list under control was to set a rule (which is pretty consistent in our family) close family only parents, siblings, grandparents aunts, uncles, first cousins only & their children. no second cousins, extended family, no dates (unless engaged) no coworkers. we also wanted a close, intimate feel to our wedding where only those who we really loved & those who really love us would be there thats why we choose a destination wedding.
best of luck with your guest list & stick to your guns once you've decided on it.