Yes, we have gone twice without our DD and are getting ready for a 3rd trip in 9 days.
The trip has a whole other emphasis when the kids aren't along. More adult oriented. We still do all of the rides, go to EE mornings, etc... but it is more relaxed and laid back. We tend to try restaurants we normally wouldn't with DD along, too. We have rented paddle boats at PO-R, had long leisurely dinners at Narcoosee's, went to Boardwalk and Pleasure Island, sat in the swings on the beach at the Poly and watched the boats with the MK in the background, drank around the world, did the monorail crawl.
The 1st time we went with DD, she was 4 and wanted to ride EVERYTHING. Problem was, she was nowhere NEAR tall enough (being very petite), so she stayed at the beach house with my parents, and was happy with that. We stayed at PO-R in the Bayou Section.
The 2nd time we went down it began as a scouting expedition for moving down, but when we decided to put off the move for a year, it just became an adult vacation. We stayed at the Contemporary, waterview north wing.
This time, we are going down to take care of things for our upcoming move, and knew if we stayed on site, it would be too distracting, so we are staying at Howard Johnson's Maingate East. DD is getting ready for state testing at school, so we didn't want to take her out for a week, and then bore her with all of the errands we will have to run while there. We will be going into the parks parts of days, but not whole days (AP's are great for that!)
Our DD has been to WDW with us 4 times in the past 2 years, so she is definitely not Disney or family vacation deprived. She knows that Mommy and Daddy need adult time, too... and she is fine with it--- when she goes we concentrate on what she wants to do, and going on our own gives us the opportunity to do and see things that she wouldn't appreciate or enjoy. We think it is very healthy.