Yippiee! I'm so glad that I've found this thread!
We've decided to drive to WDW for a little pixie dust break! We're leaving Virginia June 7th and leaving WDW on June 12th. It'll be myself, my mother, my DS6, and my twin DD's 2. We're leaving from the Richmond, Virginia area, and right now I'm planning on driving it straight through. From what I can gather, it's about a fourteen hour drive, depending on potty breaks and such. My mother and I are both used to driving long distances at night (we used to drive from NYC to South Dakota STRAIGHT THROUGH!), so I don't think VA to WDW will be too bad.
Our plan right now is to leave after dinner with the kiddos in their p.j.'s, let them watch a DVD for a while and then have them sleep, mom and I can stop and switch when we need to and we'll arrive in Orlando the next morning ready for breakfast and some Disney magic!
Thanks for all the posts and tips - I'm sure I'll have some questions as the trip gets closer!