I would fly! Its a whole lot safer and cheaper... but if you plan on driving its ok. I would stay around SC or NC. It really depends on your route. Wish I could help you out.
Just don't mistake the I-81 etc route as a "country" drive. Scenic it is. But a pleasant drive it isn't.
It certainly does beat going thru the big cities, but you will find tons of trucks along that route, especially on I-81. Believe me--you will NOT have the roads to yourself.
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