For years, we drove from south jersey to Disney. We tried leaving different times, stopping and driving straight thru. Tolls are minimal, gas, while expensive now, not so bad as your mileage on the highway is much greater. The hardest part is the boring drive after the initial excitement wears off. If possible, try Spirit, Frontier and American out of PHL. You can also check flights out of Trenton and Atlantic city. The short drive to another airport and a 2 and1/2 hour flight is much easier (but not cheaper) then the drive. This is especially true on the drive home, when the magic is over.
A lot depends on your individual situation. Full vehicle, or room to relax? One driver, or backups for breaks? Small children or adults? Driving overnight (not recommended), straight thru or overnight in a hotel. Your situation will vary, but you need to realistically access your situation. That being said, in all our trips, we were fortunate and had no major issues to consider not making the trip, and in retrospect enjoyed each and every one. Good luck and safe travels!!