Most of the low-lying spots on I-10 are in Louisiana (esp. near Crowley) and Texas, plus a couple in California. Along the Gulf Coast, closures for high water are REALLY rare, but I checked back 20 years to see what I could find. There was a closure after TS Debby (you remember, the one in 2012 that just SAT on Florida for days?), along the lower edge of the Osceola Nat'l Forest east of Lake City, FL (just east of the I-75 interchange) to Sanderson, FL @ US90. I also found a record of a floodwater closure not far east of the Louisiana border in 2016, directly north of Bay St. Louis, but that one only lasted a few hours.
Historically, I-10 through that area is more likely to close due to accidents than weather. I recommend using the WAZE app on your phone to watch for issues on the road ahead.