I'm a USC student. The USC game on the 10th is weird because it's a home game on a Thursday night. It certainly won't affect crowds.
For traffic, you shouldn't need to go by USC at all. If you're coming from Disneyland, you should take the 5 North to the 101 North. Since the game is in the evening, the game shouldn't affect traffic getting there. Leaving Universal Studios should be fine too because the game won't get out until after 10:30pm and most people aren't going on the 5 either.