Boy, do I know RLS!!! Unfortunately! I've had it for about a year and a half now...severe. Before I went to the doc's I tried everything, supplements, using the circulation socks, etc. My doc prescribed me Trazadone. It is an anti-depressant, which made me nervous....I complained that I am not depressed! Well, I guess they used to use it as an anti-dep before all the others came out, but found out in very small doses it helps RLS (I take only 25 mg a night). She assured me that the RLS had nothing to do with depression (thankfully as severe forms of depression run in my family!). I've been using it for about a year, however; I'm going to have to go back to my doc this month as I seem to have to take more and more of it to calm my right leg...so now many nights I take 1 1/2 pills. Not a big deal except these pills basically knock me for a loop...meaning I get extremely tired within 15 mins of taking it..not good for the social life when you are out at 9 pm (and my RLS kicks it like clockwork about 9 every night so I have to take them by 8:30 without fail)! I've heard there is something new out there called Requip...I'm going to ask her about that next visit. I'd be anxious to hear from any others who've tried the Requip and its affects on being so darn tired!