Here are my thoughts by land. Just my opinions of course. If you have Genie + it will make getting on the big rides a lot easier.
Main Street: Nothing to worry about here except just enjoy the ambiance and the smaller castle. If you have time to burn (doubt it) could ride a vehicle. Main thing here if you are big Disney fans would be to just enjoy Walt's original area. Say "hi" to the lamp above the fire station.
Railroad: Only if you like it or need a place to sit and rest. Some parts have nice views, some don't. For the unique part you could take it from Tomorrowland to Main Street to see the indoor scenes
Adventureland:
Tiki Room: only do if you have time left. Mostly the same
Jungle Cruise: only if you have time left. I like WDW better
Indiana Jones: Must do. Unique to Disneyland (though same vehicles and layout as AK Dinosaur)
Tarzan Treehouse: pass unless you really like Tarzan and have time. Swiss Family Treehouse at WDW much better
New Orleans Square:
This area is unique to DL so fun to explore if time
Pirates: Much better at DL and worth the time
Haunted Mansion: Basically similar experience-ish so only if time. Or if a huge fan
Critter Country:
Winnie the Pooh: similar enough to pass
Splash Mountain: pass unless a huge fan of the ride. WDW is better
Frontierland:
Big Thunder: pass unless a fan of the ride. Fairly similar. That said, one of our favorite rides
Mark Twain Riverboat: pass unless desired. Pretty ride and good view of the area. I'd only do this if you have extra time or need a short break from the lines
Toontown:
As adults I'd probably just walk through this area briefly to see it before it gets remodeled.
Roger Rabbit: unique to DL. Lines can get really long. Probably only if a fan of the movie or have extra time
Galaxy's Edge:
As you stated it is basically the same as WDW, just flipped. I'd only do if you have time and are a huge fan.
Fantasyland:
These are basically the same (yes, some differences) and I'd pass: Peter Pan, Dumbo, Carrousel, Tea Party
Mr. Toad: unique to DL. Where else can you drive crazy, die and go to he** at Disney?

Matterhorn: basic coaster but unique. Very rough. Fun for history (first tubular coaster) but not a must do
Casey Jr: fun and great view of the Storybookland area. Not a must do but fun if line is short
Storybookland Canal Boats: unique to DL and worth doing if like that type of thing. We do. Most pretty at night.
Small World: not different enough to make it worth it. But it is worth walking by to see the front (which is much better at DL) at night
Pinocchio: unique and OK if short line just to say you did it.
Alice: unique to DL and worth doing. Line can get a bit long
Snow White: same as Pinocchio. We like the new version better now
Sleeping Beauty Castle Walk-through: Doesn't take long and unique to DL. Nice to do when crowds/lines are long elsewhere
Tomorrowland:
Buzz Lightyear. Same idea as WDW but you can remove your gun and aim better. Only do if a big fan of the ride
Autopia. Pass. similar
Star Tours: Pass. similar
Space Mountain. Pass. similar
Finding Nemo Subs: unique to DL and worth it if a fan of Finding Nemo
Astro Orbiter. Pass
Monorail. Pass
Pixar Pier/Paradise Gardens:
Incredicoaster is just a roller coaster. Could do single-rider line if wish (quicker)
Toy Story Midway Mania: pass. similar
Little Mermaid. Similar. pass.
Everything else. I'd pass. Basically just themed carnival rides
Grizzly Peak:
Redwood Creek: No rides here but very pretty and worth a quick walk through to see if. Best to do when crowded/long lines elsewhere
Grizzly River Run. Basically like Kali River Rapids. Pass
Soarin. Same. pass.
Hollywood:
Mickey's Philharmagic. Pass. Better/bigger at WDW
Monsters Inc: Unique to DL. Do if a fan of the movie and line is short
Animation Building: Unique and worth walking in to see. Don't have to spend much time unless want to explore.
Avengers Campus
Unique to DL and at least worth a walk through.
See shows only if huge Avengers fan
If your stomach and head can handle Tower of Terror at WDW, definitely do Guardians.
Webslingers: unique to DL and probably worth just paying the extra fee to bypass the line
Cars land:
Must do. Unique to DL. Gorgeous at night. If it works to time it, fun to be there at official "sunset" when they light the buildings and they play "Sha-Boom"
At least do Radiator Springs Racers. If you want to ride together probably pay the extra to bypass the line. If okay in separate cars, do Single Rider
Maters: Similar to Alien Saucers so can pass. Cute to watch for a minute though
Luigi's: Unique to DL. Cute to watch for a minute. If it looks interesting do it. Otherwise move on
Shows:
Fantasmic is better at DL but harder to see due to crowds
World of Color is unique to DL/DCA and worth it if playing
Parades. Sure if a fan. Otherwise can create shorter lines to do rides instead
Going quickly. May have missed some but hopefully a helpful overview.