Both routes are nearly identical in distance. Both depend on the traffic (when you decide to travel).
Note that I-95 is under construction for the entirety of I-95 in St. Johns County. There can be delays due to construction. Also, a crane hit a northbound overpass bridge on I-95 yesterday, which is bound to effect southbound travel also (if temporary detours are necessary).
If you are travelling right away, you might consider the I-75 / Turnpike / SR 408 (Beeline) route. You will have toll stops, but should avoid most construction. However I recently drove the I-95 / I-295 / I-10 route and sailed right through - Luck of the draw?
Happy motoring and drive safe!