When you leave out of Orlando - these are the backroad directions that all the locals take to avoid all that traffic.
Take Cargo Road (looks like a back road) and follow that to Narcoossee Road, make a right on Narcoossee and 5 miles down the road is a Publix supermarket and a Walgreens. A 1/4 mile past is 417 which you need to take South and just follow the signs for Disney. This is the way the locals go.
None of us take 528 or 417 to the airport. We go through the back road. It looks like you are parallel to the runways, but it will lead you out of the airport to the main road (Narcoossee) which sits between 417 and 528.
Hope this helps.