If you use the onboard airline check-in service, they will collect your bags the night before debarkation and you will see them next at your home airport. This is not available for all airlines, check onboard to see if you qualify.
If you just have transfers, you get your luggage in the luggage hall before customs and it goes on the bus with you. You handle it at the airport, but there will be skycaps available if you need assistance.