Originally posted by Chip 'n Dale Express
It's important to note that despite the nightlife at the Boardwalk area, it doesn't recieve any special transportation. Buses pick up for Downtown Disney until approx midnight. After Midnight, some buses may be going out of service and might not return to Downtown Disney. Some might. It just depends on how the cookie crumbles with dispatching.
Buses run from Pleasure Island until 2:15am. If you miss that 2:15 bus, you will need to take a cab.