Cocoa Beach is the closest beach to Orlando (528 is a direct shot). There are a number of hotels there. We've stayed at a privately owned one, but that does not do one night stays.
We also stayed at one of the larger chain resorts right on the beach. It was ok, nothing I'd recommend.
Four Seasons is directly connected to Ron Jon's and that might be fun...
Much will depend upon how much you want to spend, and if you want directly on the beach, or simply beach access.