But none of them are exactly "decent"--most are longer distance and will take extra time. BUt you do avoid Baltimore and DC. Have a look at a map and see if that route is do-able for you.
ON 95 IF you put the pedal to the floor and don't stop except for gas, you can do it quicker than 16 hours. But don't forget--you ALSO need to get through Baltimore and Richmond on Friday afternoon, and neither is a pleasant drive. One accident or just a bit of bad weather can cause a huge delay. Once past
these spots, only Jacksonville will present any real traffic problem. But that for you will be a Saturday, so at least there won't be any rush hour.
Should say that if you leave at 1:00 on Friday, you will most likely run into DC's rush hour, which usually starts around 3:00 or so and can last until well after 6:00-6:30 PM.
Now you will certainly get through at some point, but it is a very hectic drive.Your nerves will be shot when you finally get clear of heavy traffic, which may not even be until you are well past Fredericksburg VA.
Not knowing exactly where the OP is driving from I've picked your state Capital of Harrisburg which to me seems to be in Central Pa, but I 'm not a local so don't flame me.
The below estimates times do not include, meals, calls of nature, stopping at South of the Border, Nascar Museum or Sheetz.
When we drive, from just west of Toronto, Ontario,to WDW, google estimates the drive at 21 hours we usually spend 24 to 26 hours on the road.
Route A ( google picked this route)
Harrisburg to WDW via
US 15, I-270, I-95, I-4
982 mi – about 15 hours 29 mins
http://maps.google.com/maps?f=d&hl=...885931,-81.166992&spn=15.906665,29.882813&z=5
Route B. (I slightly modified the original route)
Harrisburg to WDW via
I-83,I-695, I-95, I-495, I-95, I-4
994 mi – about 15 hours 32 mins
http://maps.google.com/maps?f=d&hl=...496456,-79.584961&spn=15.789091,29.882813&z=5
Route C (my preferred route.
Harrisburg to WDW via
1,025 mi – about 15 hours 59 mins
http://maps.google.com/maps?f=d&hl=...452218,-80.771484&spn=15.989086,29.882813&z=5
Between the three routes there is no more than 30 minutes or 3% more time by taking route C over the shortest route in estimated time.
With the OP leaving sometimes Friday afternoon By taking route C, the longest in time and distance, the only large metropolitan area they will hit will be Charlotte, NC 7 1/2 hours after they begin their trip
Not sure what you define as "decent" but an extra 30 minutes on roads with less congestion, for me, is the way to go.
Before planning a route to also want to look into whether or not when your traveling there isn't major road construction or road closures.
Happy Motoring.
How long did it take? Where did you stop for the night (assuming a stop)? 
My DH is the main driver and he likes driving the open highway but the city traffic wears him out. Therefore, the alternate route is looking like our best choice.
