International Drive is lined with hotels. The area closest to Wet n Wild is the most congested and the area south closest to SeaWorld is the least. I prefer the latter.
There are some plusses to staying on I-Drive. They have every restaurant you can imagine, and mostly everything is a walk away. Unfortunately it is a tourist trap and the traffic can be incredible so take that into consideration. Even if you're not driving, the I-Ride Trolley, taxis and the shuttles get caught up in that traffic, also.