Another difference is that in a lockoff you will have a full kitchen in the one bedroom section of the villa and a kitchenette in the studio section of the villa. In a dedicated 2 bedroom, you would not get the kitchenette.
Also, the lockoffs will have one bed and a sleeper sofa in the 2nd bedroom. Most dedicated 2 bedrooms (not all) will have 2 beds in the 2nd bedroom.