I'm not sure if this counts as a tip, but here's what works well for us:
Arrival - We schedule our flights to depart after work/school, so we get that last day of work/school in and arrive at WDW at night. When sending DD off to school that morning, I have leave a small grocery bag packed with one set of jammies, her lovie, and her toothbrush/paste. After we pick her up from school, I put that bag into her backpack (that has her homework in it, because we're the awful/awesome parents that take her out of school to take her to WDW!). When we get to the resort, DH and I just have our carryon, and DD has hers - we let ME take care of the rest. When she's ready for bed, she has all she needs. DH and I are free to hang out in the room with drinks from the lounge while we wait for the Magical Express to deliver the rest of our luggage, but know that DD is snug in bed, and will be well rested for our first day of vacation!
Laundry - I pack a new garbage bag and pop-up hamper in our suitcase. As we go through our clothes, I put lights in the garbage bag, and darks in the pop up hamper. Then one night halfway though, I do a load of laundry while we're having dinner at WCC (in our hotel). Before the main course comes, I run down and switch them over to the dryer. I pick them up after dinner on the way back to the room, where we might change for a swim, or head back out to a park. Then, as we dirty the clothes again, I throw all the dirties back into the garbage bag. Then we have one suitcase that has dirty clothes in a garbage bag, and the other suitcase holds our clean ones. Toiletries go onto whichever bag is less full. When we get home - one bag gets unpacked back into drawers, the other gets unpacked directly into the clothes hamper at home