What's the difference between these 2 hard drives?

They look like the same drive and have the same size HDDs inside. The Premium has a 1 year warranty and the Pro has a 3 year warranty. Also looks like the Pro has more advanced software (EMC Retrospect versus WD Backup).
HTH.
---Ritch
 

One difference is that apparently (if you read the fine print here, that the Pro is formatted in HPS+ for use with a Mac. It would need to be reformatted for use on a PC, presumably with NTFS if you're using Windows.

The dual drive external hard drives ship with either an NTFS (My Book Premium II) or HPS+ (My Book Pro II) partition.

They do a lousy job of explaining it... I also found some horror stories here, the original blog posting is not something I'd take seriously (one single bad experience with hard drives is nothing to go by - especially if, as the comments imply, the guy wasn't bright enough to bother checking the partitioning) but there are a fair number of comments with a range of experiences.

Considering the steep cost of this device, I'd definitely lean towards a single-drive setup, or a pair of them if you need more (you can get a 750g single drive nowadays.) Or some kind of NAS.
 













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