Haven't been lucky enough to be able to do much upscale travel.
We often travel using my inlaws time-share. So, with that option, swanky expensive hotels are not as much in the picture.
For us:
Top floor, skyline view, almost floor to ceiling picture windows, at the Intercontinental New York.
The Gaylord Opryland with their amazing indoor garden grounds. The Cascades section.
Lucked out years ago, and got a very nice top floor two bedroom suite overlooking the pools etc. on a trip to Florida/Disney.
We are considering Secrets Maroma Beach, all adult, all inclusive, on a gorgeous beach on the Maya Riviera, with an incredible rate that we had heard about. Literally half what the rates usually are.