Depends on your interests. We have salt water and fresh water for fishing and water sports. Mountains and deserts for outdoor activies, hiking and camping. Pro sports teams. Big cities or small towns. What do you enjoy? What says "vacation" to you?
In the past couple years we have taken some great little WA/OR vacations. We have split rocks to find fossils, hiked in caves, toured dams, panned for gold, visited ghost towns, saw Crater lake, saw sea lions in sea lion caves, played on the beach, visited filming locations from the Goonies movie, visited an old west town, etc, etc. The area is not lacking for interesting things to do!